Departmental Seminar: Dr. Iain Cheeseman

About this event

Guest Speaker: Iain Cheeseman, PhDProfessor of Biology at MITCore Member, Whitehead InstituteTitle: "Unlocking the Hidden Proteome" Our lab is fascinated by the molecular machinery that directs core cellular processes, and in particular how these processes are modulated and rewired across different physiological contexts. Our work has focused on the proteins that direct chromosome segregation and cell division, including the macromolecular kinetochore structure that mediates chromosome-microtubule interactions. Although cell division is an essential cellular process, this machinery is remarkably flexible in its composition and properties, which can vary dramatically between species and are even modulated within the same organism - over the cell cycle, during development\\ , and across diverse physiological situations. To define the basis by which the kinetochore and other core cellular structures are rewired to adapt to diverse situations and functional requirements, we are currently investigating diverse transcriptional, translational, and post-translational mechanisms that act to generate proteomic variability both within individual cells and across tissues, cell state, development, and disease . Student Invited Seminar Speaker 2362 lw_align_left">

Guest Speaker: Iain Cheeseman, PhD

Professor of Biology at MIT

Core Member, Whitehead Institute

Title: "Unlocking the Hidden Proteome"

Our lab is fascinated by the molecular machinery that directs core cellular processes, and in particular how these processes are modulated and rewired across different physiological contexts. Our work has focused on the proteins that direct chromosome segregation and cell division, including the macromolecular kinetochore structure that mediates chromosome-microtubule interactions. Although cell division is an essential cellular process, this machinery is remarkably flexible in its composition and properties, which can vary dramatically between species and are even modulated within the same organism - over the cell cycle, during development, and across diverse physiol ogical situations. To define the basis by which the kinetochore and other core cellular structures are rewired to adapt to diverse situations and functional requirements, we are currently investigating diverse transcriptional, translational, and post-translational mechanisms that act to generate proteomic variability both within individual cells and across tissues, cell state, development, and disease.

Stude nt Invited Seminar Speaker